研究業績

研究者情報リンク

J-GLOBALリンク

原著論文

2025年

30. Noguchi H, Yoshimura M, Watanabe A, Koyama S, Sakurada N, Shijo M, Kanemaru T, Kai K, Aishima S, Koike H, Tsuboi Y, Sasagasako N, Honda H.
    Differential pathology of P102L-associated Gerstmann-Stäussler-Scheinker disease: exclusive presence of 8-kDa protease-resistant prion protein vs. co-existence of 8-kDa and type-1 protease-resistant prion protein, with a focus on codon 129 polymorphism. Prion. 2025 Dec;19(1):50-66. doi: 10.1080/19336896.2025.2560823. 
31. Omatsu T, Koseki M, Ito K, Saga A, Sawabe H, Tanaka K, Inui H, Okada T, Nishida M, Takahashi H, Aishima S, Kamada Y, Yoshida H, Sakata Y.
    Serum Desmosterol Level Reflects Hepatic Inflammation Grade in Patients with Biopsy-Confirmed Metabolic Dysfunction-Associated Steatotic Liver Disease. J Atheroscler Thromb. 2025 Jul 16. doi: 10.5551/jat.65748.
32. Stefan L, Uehara MK, Ikegami Y, Shirakigawa N, Sakai Y, Mizumoto H, Aishima S, Yamashita YI, Ijima H.
    Early-stage transplant responses in miniature-liver implants based on decellularization-recellularization technology. J Biosci Bioeng. 2025 Oct;140(4):244-251. doi: 10.1016/j.jbiosc.2025.06.005. 
33. Shimada Y, Yamamoto T, Shindo K, Nakanishi Y, Matsumoto T, Noguchi S, Aishima S, Nakamura M, Oda Y.
    Clinicopathologic and Genomic Features of Gastric-Type Intraductal Papillary Neoplasm of the Bile Duct: Potential Role of STK11 in Malignant Progression. Am J Surg Pathol. 2025 Oct 1;49(10):1004-1014. doi: 10.1097/PAS.0000000000002451.
34. Kawanaka M, Fujii H, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Kamada Y, Takahashi H, Ueda S, Aishima S, Nishino K, Ishii K, Fushimi T, Kawamoto H, Sumida Y, Okanoue T, Nakajima A, Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld.
    Tips for Hepatologist Referral of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease with Alanine Aminotransferase Levels ≤ 30 U/L. Diagnostics (Basel). 2025 Jun 23;15(13):1591. doi: 10.3390/diagnostics15131591.
35. Kohira T, Oeda S, Eto E, Kubotsu Y, Norita M, Inoue K, Hara N, Noge S, Tanaka K, Yoshimura S, Oza N, Anzai K, Eguchi Y, Ng CH, Huang DQ, Muthiah MD, Kawaguchi A, Aishima S, Isoda H, Kuwashiro T, Takahashi H.
    Quantification of liver steatosis of metabolic dysfunction-associated steatotic liver disease based on body composition analysis. Sci Rep. 2025 Aug 30;15(1):31982. doi: 10.1038/s41598-025-17396-1
36. Ishiba H, Sumida Y, Kamada Y, Fujii H, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Takahashi H, Ueda S, Aishima S, Nakajima A, Okanoue T; Japan Study Group of Non-alcoholic Fatty Liver Disease (JSG-NAFLD).
    Prediction of Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease by Type IV Collagen 7S. Gastro Hep Adv. 2025 Mar 28;4(7):100668. doi: 10.1016/j.gastha.2025.100668. eCollection 2025.
37. Li J, Xu L, Rui F, Tran S, Tsai PC, Tan Y, Toyoda H, Zeng QL, Trinh H, Hsu YC, Watanabe T, Abe H, Motoyama H, Yoshimaru Y, Suzuki T, Arai T, Atsukawa M, Vutien P, Marciano S, Bai X, Ni W, Geng N, Tseng CH, Liu J, Mi Y, Liu J, Ye Y, Zhu L, Chen RY, Zhu C, Maeda M, Liu JK, Henry L, Yeh ML, Huang CF, Huang JF, Dai CY, Gadano A, Cheung R, Chuang WL, Enomoto M, Tanaka Y, Aishima S, Yu ML, Wu C, Shi J, Nguyen MH.
    Type 2 diabetes mellitus as an independent predictor of significant fibrosis in treatment-naïve chronic hepatitis B patients with concurrent hepatic steatosis. Hepatology. 2025 Jun 25. doi: 10.1097/HEP.0000000000001442.
38. Tadokoro T, Kawanaka M, Takahashi H, Aishima S, Zhao W, Yano R, Takuma K, Nakahara M, Oura K, Fujita K, Kobayashi K, Mimura S, Tani J, Morishita A, Haba R, Masaki T, Kobara H, Ono M.
    A Noninvasive Method of Diagnosing Metabolic Dysfunction-Associated Steatohepatitis Using Cytokeratin-18 Fragment and FIB-3 Index. Diagnostics (Basel). 2025 Apr 17;15(8):1023. doi: 10.3390/diagnostics15081023
39. Wu L, Zhou Y, Zhang Y, Hu J, Ikegami Y, Aishima S, Ijima H.
    Fast Wound Healing with a New Functional Hyaluronic Acid Dual Network Hydrogel. Gels. 2025 Apr 3;11(4):266. doi: 10.3390/gels11040266
40. Takedomi H, Nunomura S, Nanri Y, Honda Y, Yokomizo K, Akutagawa T, Tsuruoka N, Sakata Y, Conway S, Kawaguchi A, Aishima S, Esaki M, Izuhara K.
    Serum Periostin is Able to Stratify Type 2-Dominant Ulcerative Colitis. Inflamm Bowel Dis. 2025 Jan 27:izaf009. doi: 10.1093/ibd/izaf009
41. Imajo K, Saigusa Y, Kobayashi T, Nagai K, Nishida S, Kawamura N, Doi H, Iwaki M, Nogami A, Honda Y, Kessoku T, Ogawa Y, Kirikoshi H, Kokubu S, Utsunomiya D, Takahashi H, Aishima S, Sumida Y, Saito S, Yoneda M, Dennis A, Kin S, Andersson A, Nakajima A.
    Head-to-head comparison among FAST, MAST, and multiparametric MRI-based new score in diagnosing at-risk MASH. Eur Radiol. 2025 Jun;35(6):3599-3609. doi: 10.1007/s00330-024-11215-3

2024年

18. Ishiba H, Fujii H, Kamada Y, Sumida Y, Takahashi H, Seko Y, Toyoda H, Hayashi H, Yamaguchi K, Iwaki M, Yoneda M, Arai T, Shima T, Morishita A, Kawata K, Tomita K, Kawanaka M, Yoshida Y, Ikegami T, Notsumata K, Oeda S, Fukushima H, Miyoshi E, Aishima S, Itoh Y, Okanoue T, Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).
    Accuracy of type IV collagen 7S versus Enhanced Liver Fibrosis score for diagnosing fibrosis in patients with metabolic dysfunction-associated steatotic liver disease. Hepatol Commun. 2024 Dec 11;9(1):e0563. doi: 10.1097/HC9.0000000000000563
19. Zhang Y, Fardous J, Zhou Y, Wu L, Doi R, Hu J, Hirota Y, Ikegami Y, Aishima S, Ijima H.
    Topical delivery of gel-in-oil emulsion cocktail with growth factors for the treatment of diabetic pressure ulcers. J Biosci Bioeng. 2025 Feb;139(2):112-122. doi: 10.1016/j.jbiosc.2024.10.011
20. Nouso K, Kawanaka M, Fujii H, Kariyama K, Toyoda H, Iwaki M, Hayashi H, Oeda S, Hyogo H, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Kamada Y, Takahashi H, Ueda S, Aishima S, Sumida Y, Nakajima A, Kumada T, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD).
    Validation study of age-independent fibrosis score (Fibrosis-3 index) in patients with metabolic dysfunction-associated steatotic liver disease. Hepatol Res. 2024 Oct;54(10):912-920. doi: 10.1111/hepr.14039
21. Tsutsumi T, Kawaguchi T, Fujii H, Kamada Y, Takahashi H, Kawanaka M, Sumida Y, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Morishita A, Munekage K, Kawata K, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Ueda S, Aishima S, Nakajima A, Okanoue T.
    Hepatic inflammation and fibrosis are profiles related to mid-term mortality in biopsy-proven MASLD: A multicenter study in Japan. Aliment Pharmacol Ther. 2024 Jun;59(12):1559-1570. doi: 10.1111/apt.17995
22. Koyama S, Yagita K, Hamasaki H, Noguchi H, Shijo M, Matsuzono K, Takase KI, Kai K, Aishima SI, Itoh K, Ninomiya T, Sasagasako N, Honda H.
    Novel method for classification of prion diseases by detecting PrP^res signal patterns from formalin-fixed paraffin-embedded samples. Prion. 2024 Dec;18(1):40-53. doi: 10.1080/19336896.2024.2337981
23. Iwaki M, Fujii H, Hayashi H, Toyoda H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Kamada Y, Takahashi H, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T.
    Prognosis of biopsy-confirmed metabolic dysfunction- associated steatotic liver disease: A sub-analysis of the CLIONE study. Clin Mol Hepatol. 2024 Apr;30(2):225-234. doi: 10.3350/cmh.2023.0515
24. Nakanuma Y, Sato Y, Kakuda Y, Naito Y, Fukumura Y, Fukushima M, Minato H, Aishima S, Ohike N, Furukawa T. Interobserver agreement of pathologic classification and grading of tumoral intraductal pre-invasive neoplasms of the bile duct. Ann Diagn Pathol. 2024 Apr;69:152247. doi: 10.1016/j.anndiagpath.2023.152247
25. Arai T, Takahashi H, Seko Y, Toyoda H, Hayashi H, Yamaguchi K, Iwaki M, Yoneda M, Shima T, Fujii H, Morishita A, Kawata K, Tomita K, Kawanaka M, Yoshida Y, Ikegami T, Notsumata K, Oeda S, Atsukawa M, Kamada Y, Sumida Y, Fukushima H, Miyoshi E, Aishima S, Okanoue T, Itoh Y, Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).
26. Accuracy of the Enhanced Liver Fibrosis Test in Patients With Type 2 Diabetes Mellitus and Its Clinical Implications. Clin Gastroenterol Hepatol. 2024 Apr;22(4):789-797.e8. doi: 10.1016/j.cgh.2023.11.022

2023年

1. Toyoda H, Fujii H, Iwaki M, Hayashi H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Yamamura S, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Kawada N, Tokushige A, Kamada Y, Takahashi H, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).
   Validation of Noninvasive Markers for HCC Risk Stratification in 1389 Patients With Biopsy-proven NAFLD. Gastro Hep Adv. 2023 Aug 2;2(8):1093-1102. doi: 10.1016/j.gastha.2023.07.018
2. Zhang Y, Fardous J, Inoue Y, Doi R, Obata A, Sakai Y, Aishima S, Ijima H.
   Subcutaneous angiogenesis induced by transdermal delivery of gel-in-oil nanogel dispersion. Biomater Adv. 2023 Nov;154:213628. doi: 10.1016/j.bioadv.2023.213628
3. Ito T, Morooka H, Takahashi H, Fujii H, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Ishigami M, Kamada Y, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).
   Identification of clinical phenotypes associated with poor prognosis in patients with nonalcoholic fatty liver disease via unsupervised machine learning. J Gastroenterol Hepatol. 2023 Oct;38(10):1832-1839. doi: 10.1111/jgh.16326
4. Takahashi H, Kawanaka M, Fujii H, Iwaki M, Hayashi H, Toyoda H, Oeda S, Hyogo H, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Kamada Y, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T, Japan Study Group Of Nonalcoholic Fatty Liver Disease Jsg-Nafld.
   Association of Serum Albumin Levels and Long-Term Prognosis in Patients with Biopsy-Confirmed Nonalcoholic Fatty Liver Disease. Nutrients. 2023 Apr 22;15(9):2014. doi: 10.3390/nu15092014
5. Bishop JA, Weinreb I, van Vliet C, Leslie C, Utsumi Y, Aishima S, Shiraishi J, Koyama M, Nara Y, Kimura M, Palsgrove D, Kuo YJ, Gilbert R, Gagan J, Nakaguro M, Nagao T.
   Palisading Adenocarcinoma: A Morphologically Unique Salivary Gland Tumor With a Neuroendocrine-like Appearance and a Predilection for the Sublingual Glands of Women. Am J Surg Pathol. 2023 Oct 1;47(10):1176-1185. doi: 10.1097/PAS.0000000000002091
6. Miura K, Hayashi H, Kamada Y, Fujii H, Takahashi H, Oeda S, Iwaki M, Kawaguchi T, Tomita E, Yoneda M, Tokushige A, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease.
   Agile 3+ and Agile 4, noninvasive tests for liver fibrosis, are excellent formulae to predict liver-related events in nonalcoholic fatty liver disease. Hepatol Res. 2023 Oct;53(10):978-988. doi: 10.1111/hepr.13938
7. Takahashi Y, Yamaguchi T, Otsubo T, Nakashima K, Shinzato K, Osako R, Shichida S, Kawano Y, Fukui A, Kawaguchi A, Aishima S, Saito T, Takahashi N, Node K.
   Histological validation of atrial structural remodelling in patients with atrial fibrillation. Eur Heart J. 2023 Sep 14;44(35):3339-3353. doi: 10.1093/eurheartj/ehad396
8. Imajo K, Saigusa Y, Kobayashi T, Nagai K, Nishida S, Kawamura N, Doi H, Iwaki M, Nogami A, Honda Y, Kessoku T, Ogawa Y, Kirikoshi H, Yasuda S, Toyoda H, Hayashi H, Kokubu S, Utsunomiya D, Takahashi H, Aishima S, Kim BK, Tamaki N, Saito S, Yoneda M, Loomba R, Nakajima A.
   M-PAST score is better than MAST score for the diagnosis of active fibrotic nonalcoholic steatohepatitis. Hepatol Res. 2023 Sep;53(9):844-856. doi: 10.1111/hepr.13927
9. Hayashi H, Kamada Y, Fujii H, Takahashi H, Oeda S, Iwaki M, Kawaguchi T, Tomita E, Yoneda M, Tokushige A, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD).
   Prediction of Liver-Related Events With a Combination of Liver Stiffness Measurements and Controlled Attenuation Parameters in Japanese Patients With Biopsy-Proven Non-alcoholic Fatty Liver Disease. Ultrasound Med Biol. 2023 Jul;49(7):1658-1664. doi: 10.1016/j.ultrasmedbio.2023.03.023

総説

• Aishima S, Oda Y.
  Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type. J Hepatobiliary Pancreat Sci. 2015 Feb;22(2):94-100. doi: 10.1002/jhbp.154

症例報告

1. Iwasaki H, Itoh S, Toshima T, Iwasaki T, Ushijima Y, Aishima S, Ishigami K, Oda Y, Yoshizumi T.
   [A case of a liver mass detected incidentally by health examination]. Nihon Shokakibyo Gakkai Zasshi. 2025;122(7):520-525. doi: 10.11405/nisshoshi.122.520.
2. Nakamura K, Ozono Y, Hasuike S, Hatada H, Uchiyama N, Komaki Y, Iwakiri H, Nagata K, Umekita Y, Aishima S, Kawakami H.
   Hepatic focal nodular hyperplasia after liver transplantation: case report and review of literature. Clin J Gastroenterol. 2025 Oct;18(5):910-917. doi: 10.1007/s12328-025-02180-5.
3. Murakami M, Fujimori N, Noguchi S, Yamamoto T, Matsumoto K, Ueda K, Ikenaga N, Aishima S, Nakamura M, Ogawa Y.
   Difficult-to-diagnose duodenal adenocarcinoma with rare invasive form. Clin J Gastroenterol. 2025 Aug;18(4):639-645. doi: 10.1007/s12328-025-02157-4. 
4. Matsumoto M, Osato S, Oishi C, Mizokami K, Hosokawa K, Yoshida K, Abe K, Oda Y, Aishima S.
   Autopsy Case of Severe Right Heart Failure Accompanied by Pulmonary Arterial Hypertension With Suspected Osler’s Disease. Pathol Int. 2025 Apr 23. doi: 10.1111/pin.70017
5. Hirose K, Toshima T, Tobo T, Kai S, Hirakawa M, Higuchi S, Ofuchi T, Hosoda K, Yonemura Y, Hisamatsu Y, Masuda T, Aishima S, Mimori K.
   A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma. Surg Case Rep. 2024 Feb 1;10(1):30. doi: 10.1186/s40792-024-01820-1
6. Ide T, Ebashi R, Eriguchi M, Aishima S, Abe T, Hara H.
   Fulminant demyelinating disease of the central nervous system effectively treated with a combination of decompressive craniectomy and immunotherapy: A case report and literature review. Clin Case Rep. 2024 Jul 9;12(7):e9059. doi: 10.1002/ccr3.9059
7. Tasaki A, Fukuda M, Ikeda Y, Yamasaki M, Yamaguchi I, Aishima S, Miyazono M.
   Pseudohypercreatininemia after surgery for aortic dissection: a case report. BMC Nephrol. 2023 Jul 25;24(1):220. doi: 10.1186/s12882-023-03275-2

著書

• わかりやすい病理学改訂第7版（南江堂）
  
  https://www.nankodo.co.jp/g/g9784524226542/?srsltid=AfmBOoq4wNkse5k_VYQzfF6AvhGny-YlNh7-qjfT9hVQN4DSEIhG60bw

受賞

• 2003年　IAP日本支部　病理診断学術奨励賞
• 2007年　日本病理学会　学術研究賞
• 2010年　日本癌学会　学術奨励賞
• 2025年　日本消化器癌発生学会　田原榮一賞

倫理委員会の承認を受けた研究

• High grade PanINの組織学的診断基準策定（M24047）
• 肝生検を施行された脂肪肝患者における肝病態及び肝外合併症の疫学に関する多施設共同研究（M25033）
• 肺扁平上皮癌の病理学的な鑑別（25063）
• 混合型肝癌における胆管癌成分の亜型・表現型の病理組織学的検討（25091)
• 乳癌における免疫微小環境の解明（25102）
• RAS変異型大腸癌肝転移の病理組織学的検討（25128）
• EUS下肝生検と経皮的肝生検による脂肪肝診断の有用性の比較：RCTデータに基づくサブグループ解析（M25069）